Anesth Pain Med Search


Anesth Pain Med > Volume 10(4); 2015 > Article
Anesthetic Pharmacology
Anesthesia and Pain Medicine 2015;10(4):267-270.
DOI:    Published online October 31, 2015.
A case of postoperative serotonin syndrome following the administration of fentanyl, palonosetron, and meperidine: A case report
Chiu Lee, Eun Ju Kim, Soohyun Joe, Jong Seouk Ban, Ji Hyang Lee, Ji Hyun An
1Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea.
2Department of Psychiatry, Ulsan University Hospital, Ulsan, Korea.
Received: 28 April 2015   • Revised: 1 July 2015   • Accepted: 8 July 2015
Serotonin syndrome is an unexpected adverse reaction of serotonergic medication. Some drugs used by anesthesiologists may cause serotonin syndrome. Serotonin syndrome is known to be related to 5-hydroxytryptamine 1A and 5-hydroxytryptamine 2A agonism. However, recent research has revealed evidence that 5-hydroxytryptamine 3 (5-HT3) antagonism can also play a role in serotonin syndrome. Among the 5-HT3 antagonists, palonosetron is the most highly specific. In this study, we present the first case of fentanyl- and meperidine-induced serotonin syndrome precipitated by palonosetron in general anesthesia.
Key Words: Fentanyl, Meperidine, Palonosetron, Serotonin, Serotonin syndrome

Article category

Browse all articles >


Browse all articles >

Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail:                

Copyright © 2024 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next