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Anesth Pain Med > Volume 10(4); 2015 > Article
Anesthetic Pharmacology
Anesthesia and Pain Medicine 2015;10(4):257-260.
DOI:    Published online October 31, 2015.
Preventive effect of ketamine gargling for postoperative sore throat after endotracheal intubation
Hee Yong Kang, Dae Young Seo, Jeong Hyun Choi, Sung Wook Park, Wha Ja Kang
Department of Anesthesiology and Pain Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Korea.
Received: 20 March 2015   • Revised: 7 April 2015   • Accepted: 19 May 2015
Postoperative sore throat (POST) is a relatively common complication after endotracheal intubation, and various methods has been proposed to prevent it. In the present study, we assessed the effectiveness of ketamine gargling for reducing POST.
This study was conducted in a prospective, randomized, placebo-controlled, and single-blinded manner. The study populations consisted of 40 patients between 20 and 60 years old who were classified as American Society of Anesthesiologists physical status I-II and were scheduled for elective laparoscopic cholecystectomy. Patients in group K received ketamine (1 ml, 50 mg) in normal saline (29 ml), and they gargled with the given solution for 30 s before induction. Patients in group C received normal saline (30 ml) and gargled it for 30 s before induction. All patients were interviewed 1, 6, and 24 h after the operation. The visual analog scale (VAS) score of POST was checked.
The VAS scores of POST were significantly lower in group K than in group C at 1 and 6 h after the operation. However, there were no significant differences in VAS scores at 24 h after the operation.
Preoperative ketamine gargling temporarily reduced POST in patients that underwent laparoscopic cholecystectomy.
Key Words: Gargle, Ketamine, Postoperative sore throat

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