| How to design intravenous anesthetic dose regimens based on pharmacokinetics and pharmacodynamics principles |
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Jong Cook Park |
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Department of Anesthesiology and Pain Medicine, Jeju National University School of Medicine, Jeju, Korea. pjcook@jejunu.ac.kr |
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Received: 7 August 2015 • Revised: 5 October 2015 • Accepted: 6 October 2015 |
| Abstract |
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Pharmacokinetics is the study of the rate and degree of drug transport to various tissues in the human body. Pharmacokinetic parameters summarize drug kinetics and ideally predict a clinical situation. A single kinetic profile may be summarized by peak concentration, peak time, half-life and area under the curve. Dosage regimens are designed to confer the maximum desired effects for the required time period with minimal toxicity. Target-controlled infusions use pharmacokinetic models to titrate intravenous anesthetic administration to achieve a desired drug concentration. Context-sensitive half time is used to predict the clinical time course, rather than terminal half-life. It is important that anesthesiologists understand the basic pharmacological principles and apply them in their daily clinical practice. This review discusses the ways in which anesthesiologists can design a patient-specific dosage regimen of intravenous anesthetics by utilizing basic concepts of pharmacokinetics and pharmacodynamics using pharmacokinetic simulations. |
| Key Words:
Intravenous anesthetics, Pharmacodynamics, Pharmacokinetic parameter, Pharmacokinetics, Target controlled infusion |
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