Opioid pharmacogenetics in anesthesia and pain management

Kim, Kye Min

doi:2015.10.2.65

Anesth Pain Med > Volume 10(2); 2015 > Article

Review

Anesthetic Pharmacology

Anesthesia and Pain Medicine 2015;10(2):65-76.
DOI: https://doi.org/10.17085/apm.2015.10.2.65 Published online April 30, 2015.

Opioid pharmacogenetics in anesthesia and pain management

Kye Min Kim

Department of Anesthesiology and Pain Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. kyemin@paik.ac.kr

Received: 11 February 2015 • Revised: 11 February 2015 • Accepted: 14 February 2015

Abstract

Opioids are the cornerstone for treating moderate to severe pain and are commonly used for anesthesia and pain management. However, large inter-individual variability exists in the analgesic and adverse effects. It would be very helpful to predict the opioid response of each patient, considering the serious outcomes related to insufficient pain control and fatal side effects. Pharmacogenetic data on opioids have accumulated; thus, the aim of this article is to review the pharmacogenetic studies related to opioids frequently used for anesthesia and pain management.

Key Words: Analgesia, Anesthesia, Opioid, Pharmacogenetics