Effect of midazolam pretreatment on desflurane MAC(BAR) at an effect-site concentration of remifentanil 1.0 ng/ml

No, Min Young; Han, Sun Sook; Kim, Tae Hee

doi:2015.10.1.27

Anesth Pain Med > Volume 10(1); 2015 > Article

Clinical Research

Anesthetic Pharmacology

Anesthesia and Pain Medicine 2015;10(1):27-31.
DOI: https://doi.org/10.17085/apm.2015.10.1.27 Published online January 31, 2015.

Effect of midazolam pretreatment on desflurane MAC(BAR) at an effect-site concentration of remifentanil 1.0 ng/ml

Min Young No, Sun Sook Han, Tae Hee Kim

Department of Anesthesiology and Pain Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. hss9438@empal.com

Received: 1 August 2014 • Revised: 14 December 1901 • Accepted: 26 December 2014

Abstract

BACKGROUND
The goal of this prospective study was to determine the effect of midazolam pretreatment on the desflurane requirement for blunting the sympathetic response after surgical incision (minimum alveolar concentration blockade of adrenergic responses, MAC(BAR)) when desflurane is combined with a target-controlled concentration of remifentanil at 1 ng/ml.
METHODS
Sixty-five patients aged 30 to 60 years with American Society of Anesthesiologists physical status of I or II who were undergoing general anesthesia for thyroidectomy were registered for this study. The patients were randomly allocated to receive either 30 microg/kg of midazolam (Group M) or isovolemic saline (Group C) intravenously before anesthetic induction. All patients were anesthetized with propofol, rocuronium, desflurane and remifentanil at a target-controlled effect-site concentration of 3 ng/ml at intubation followed by 1 ng/ml throughout the study. Sympathetic responses to surgical incision were determined 10 minutes after stabilization of end-tidal desflurane and target-controlled remifentanil concentrations. The predetermined end-tidal desflurane concentrations and MAC(BAR) for each group were determined using an up-and-down sequential allocation technique.
RESULTS
The MAC(BAR) of desflurane with 1 ng/ml remifentanil concentration was 7.1 and 6.8% without and with midazolam pretreatment, respectively, using Dixon's up-and-down method (P = 0.755).
CONCLUSIONS
Midazolam administered intravenously before anesthetic induction does not impact the MAC(BAR) of desflurane with an effect-site concentration of remifentanil 1.0 ng/ml.

Key Words: Desflurane, Midazolam, Minimum alveolar concentration, Remifentanil