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Anesthetic Pharmacology
Anesthesia and Pain Medicine 2013;8(1):16-20.
Published online January 31, 2013.
The comparison of QTc interval change on the ECG during laparoscopic cholecystectomy under inhalation and total intravenous anesthesia
Hyo Jin Byon, Seong Jin Jeong, Hyun Jun Jung, Hyun Soo Ahn, Hong Sik Lee, Choon Soo Lee, Jang Ho Song
Department of Anesthesiology and Pain Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.
There can be changes in the cardiac function during laparoscopic cholecystectomy. In this study, QTc interval changes were compared between total intravenous anesthesia (TIVA) group and inhalation anesthesia group during laparoscopic cholecystectomy.
The study was conducted on adult patients, ages ranging from 20 to 65 years old, and classified as the American Society of Anesthesiologists physical status I or II. At random, the patients were divided into group 1 (TIVA, n = 20) and group 2 (inhalation anesthesia, n = 19). Group 1 patients were induced and maintained with continuous infusion of remifentanil and propofol using a target controlled infusion device. Patients in group 2 were induced with sevoflurane and N2O using mask ventilation, and then anesthesia was maintained with sevoflurane and N2O. The QTc interval, heart rate and mean arterial pressure were measured prior to induction, immediately following intubation, 10 minutes following intubation, following CO2 inflation, immediately following head-up position, 10 minutes following head-up position, following CO2 deflation-supine position respectively.
In group 1, the ECG sampling showed no prolongation in the QTc intervals at all measured points. In group 2, QTc interval was significantly longer at all other measured points compared to prior to induction (P < 0.05). Except prior to induction, QTc intervals were significantly longer at all other measure points in group 2 compared to those in group 1 (P < 0.05).
There was no QTc interval prolongation under the TIVA using propofol and remifentanil during laparoscopic cholecystectomy.
Key Words: Cholecystectomy, Laparoscopic, Propofol, QTc interval, Remifentanil, TIVA

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