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Experimental Research
Neuroanesthesia
Anesthesia and Pain Medicine 2012;7(4):338-342.
Published online October 31, 2012.
The neuroprotective effect of colloids in forebrain ischemia model
Hye Min Sohn, Young Tae Jeon, Jung Won Hwang, Hee Pyoung Park, Young Jin Lim, Sun Hye Kang
1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. ytjeon@snubh.org
2Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.
Abstract
BACKGROUND
The aim of this study was to investigate the neuroprotective effects of colloids (albumin and pentastarch) after forebrain global ischemia in rats.
METHODS
Thirty male Sprague-Dawley rats were randomly assigned to three groups; control, albumin and pentastarch group (each n = 10). Forebrain ischemia was induced by bilateral common carotid artery occlusion plus hemorrhagic hypotension. The control group received no treatment. The albumin group received 5 ml/kg of 20% albumin after ischemia. The pentastarch group received same volume of albumin after ischemia. Histologic outcomes were measured at 7 days after ischemia in CA1 pyramidal cells of the rat hippocampus.
RESULTS
The mean percentage of viable cells in the hippocampal CA1 area was significantly higher in the albumin (47%) compared with the control group (33%) or pentastarch group (33%) (P = 0.001). The percentage of apoptotic cells was significantly lower in the albumin (30%) group than that in the pentastarch (44%) or control group (49%) (P = 0.006).
CONCLUSIONS
This study shows that albumin can improve histologic outcomes after forebrain global ischemia compared with pentastarch.
Key Words: Albumin, Brain ischemia, Hippocampus, Pentastarch
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