Anesth Pain Med Search

CLOSE


Anesthetic Pharmacology
Anesthesia and Pain Medicine 2011;6(1):37-40.
Published online January 31, 2011.
The effect of plasma 5-hydroxy indole acetic acid (5-HIAA) concentration and serotonin receptor polymorphism on postoperative nausea and vomiting (PONV)
Nam Su Gil, In Ae Song, Hyo Seok Na, Jung Min Lee, Hee Pyoung Park, Young Tae Jeon, Jung Won Hwang, Sang Hwan Do
1Department of Anesthesiology and Pain Medicine, Boramae Hospital, Seoul, Korea.
2Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. jungwon@snubh.org
3Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.
Abstract
BACKGROUND
Post-operative nausea and vomiting (PONV) is a common problem in the patients undergoing laparoscopic surgery. The release of serotonin during surgical procedure may induce PONV. We investigated if postoperative increase in plasma serotonin metabolite and genotype of serotonin receptor were associated with PONV after gynecologic laparoscopic surgery.
METHODS
The patients who experienced nausea after gynecologic laparoscopic surgery (PONV group, n = 20) and who had no or mild nausea (control group, n = 20) were enrolled. Median value of nausea (100 mm visual analogue scale, VAS) was 0 (0-20) in control group and 60 (40-100) in PONV group (P < 0.001). Postoperative nausea was assessed during 1 hr in post-anesthetic care unit. Blood samples were obtained before anesthesia and 1 hr after surgery. Plasma serotonin metabolite (5-hydroxy indole acetic acid, 5-HIAA) was analyzed using high performance liquid chromatography (HPLC) assay. Perioperative change of plasma 5-HIAA and Pro16Ser genotypes were compared between groups.
RESULTS
Average 5-HIAA concentration of all patients increased after surgery (3.65 +/- 0.90 to 4.36 +/- 1.17 ng/ml, P < 0.001). Baseline plasma 5-HIAA concentrations were similar between groups, but, 5-HIAA of PONV group increased higher after laparoscopic surgery compared with control group (3.69 +/- 0.89 to 4.62 +/- 1.12 ng/ml vs. 3.61 +/- 0.93 to 4.10 +/- 1.20 ng/ml, P = 0.03). Pro16Ser genotypes were not different between groups.
CONCLUSIONS
The patients who experienced post-operative nausea showed more increase in 5-HIAA concentration. PONV after gynecologic laparoscopic surgery may be associated with a peripheral release of serotonin.
Key Words: General anesthesia, Postoperative nausea and vomiting, Serotonin


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
101-3503, Lotte Castle President, 109 Mapo-daero, Mapo-gu, Seoul 04146, Korea
Tel: +82-2-792-5128    Fax: +82-2-792-4089    E-mail: journal@anesthesia.or.kr                

Copyright © 2023 by Korean Society of Anesthesiologists.

Developed in M2PI

Close layer
prev next