Effect of bronchodilator on bronchial mucus transport velocity during inhalational anesthesia

Kim, Young Jae; Kim, Myoung Hun; Kim, Hyun Sik; Cho, Kwang Rae; Lim, Se Hun; Lee, Jeong Han; Lee, Kun Moo; Cheong, Soon Ho; Shin, Chee Mahn

Clinical Research

Cardiothoracic and Vascular Anesthesia

Anesthesia and Pain Medicine 2010;5(4):310-313.
Published online October 31, 2010.

Effect of bronchodilator on bronchial mucus transport velocity during inhalational anesthesia

Young Jae Kim, Myoung Hun Kim, Hyun Sik Kim, Kwang Rae Cho, Se Hun Lim, Jeong Han Lee, Kun Moo Lee, Soon Ho Cheong, Chee Mahn Shin

Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan, Korea. aneskyj@inje.ac.kr

Abstract

BACKGROUND
Volatile-based anesthesia resulted in a significantly reduced cilia beat frequency. This study was to evaluate the effect of bronchodilator on bronchial mucus transport (BMT) distance measured with a bronchoscope during Inhalational anesthesia.
METHODS
Twenty-four adult patients undergoing elective orthopedic surgery under inhalation anesthesia using sevoflurane and nitrous oxide were included. Twenty minutes after tracheal intubation, they were manually inspired without nebulization of salbutamol (control group: n = 12) or with nebulization of salbutamol(salbutamol group: n = 12). And then a single drop of 0.02 ml methylene blue was applied to the posterior mucosal surface of the right main bronchus 5 cm away from the carina under the bronchoscope. The distance of dye movement was measured 5 min after its application.
RESULTS
BMT distance and velocity of methylene blue during 5min were 6.2 +/- 3.1 mm and 1.2 +/- 0.6 mm/min in control group, and 23.3 +/- 16.6 mm and 4.7 +/- 3.3 mm/min in salbutamol group, respectively. BMT distance and velocity of methylene blue in salbutamol group were longer and faster than those in control group(P < 0.05).
CONCLUSIONS
Salbutamol facilitates the transport of bronchial secretion under sevoflurane-based inhalational anesthesia in term of BMT velocity.

Key Words: Bronchial mucus transport, Bronchodilator, Inhalational anesthesia