Effective Dose of Propofol for Anesthetic Induction in Korean

Lee, Jung Moo; Lee, Soo Il; Lee, Jong Hwan; Lee, Seung Cheol

Clinical Research

Anesthetic Pharmacology

Anesthesia and Pain Medicine 2007;2(4):206-210.
Published online October 30, 2007.

Effective Dose of Propofol for Anesthetic Induction in Korean

Jung Moo Lee, Soo Il Lee, Jong Hwan Lee, Seung Cheol Lee

Department of Anesthesiology and Pain Medicine, College of Medicine, Dong-A University, Busan, Korea. silee@dau.ac.kr

Abstract

BACKGROUND
There are few studies about the effective dose (ED) of propofol for anesthetic induction in Korean. The purpose of this study is to estimate the ED of propofol for anesthetic induction in Korean. METHODS: We studied 120 patients, who were class I or II of ASA physical status. All patients were allocated to six dose groups. Each dose group consisted of 10 men and 10 women. They were administered each 1.0 mg/kg, 1.4 mg/kg, 1.6 mg/kg, 1.8 mg/kg, 2.0 mg/kg and 2.2 mg/kg of propofol. Propofol was injected intravenously within 15 seconds. During 100% oxygen through mask ventilation, we evaluated response for verbal command and gentle shaking every 30 seconds. The end point was unconsciousness that patients fell the bar gripped with their hand. We recorded BIS value at end point. The ED estimates were calculated by logit model. Result were expressed as mean +/- SD or 95% confidence interval. RESULTS: The ED5, ED25, ED50, ED75, and ED95 of falling the bar were 1.05 mg/kg (95% CI:0.7-1.24), 1.41 mg/kg (95% CI:1.17-1.6), 1.67 mg/kg (95% CI:1.47-2.0), 1.99 mg/kg (95% CI:1.73-2.67), 2.66 mg/kg (95% CI:2.16-4.58). CONCLUSIONS: The ED50 and ED95 of falling object response were 1.67 mg/kg, 2.66 mg/kg. The appropriate induction dosage of propofol is 2.66 mg/kg without premedication.

Key Words: bispectral index, effective dose, induction, propofol