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General Article
Anesthesia and Pain Medicine 2007;2(3):151-155.
Published online July 31, 2007.
Effect of N-acetyl-cysteine on Allodynia in a Chronic Post-ischemia Pain Model of Rat
In Ho Ha, Chang Gyu Han, Kyung Hwa Kwak, Young Hoon Jeon, Sung Sik Park, Jung Gil Hong, Dong Gun Lim
1Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Korea. dglim@knu.ac.kr
2Department of Anesthesiology and Pain Medicine, School of Medicine, Wooridul Hospital, Daegu, Korea.
Abstract
BACKGROUND
Complex regional pain syndrome type I (CRPS-I) is a clinical syndrome that is poorly understood and difficult to treat. Reactive oxygen species (ROS) and inflammatory responses may contribute to the development of CRPS-I. This study evaluated the effect of N-acetyl-cysteine (NAC) on both mechanical and cold allodynia in a rat CRPS-I model. METHODS: Male adult SD rats were used for the CRPS-I model that was produced following prolonged hindpaw ischemia/reperfusion. The rats were divided into 3 groups, Group O (-) (n = 8): rats without a tourniquet; Group O (+) (n = 8): rats received ischemic injury with a tourniquet on the hindpaw and they were reperfused 3 hours after the tourniquet application; and Group ON (+) (n = 8): rats received ischemic injury with a tourniquet ring on the hindpaw and they were reperfused 3 hours after the tourniquet application and they received intraperitoneal N-cetyl-ysteine (500 mg/kg) injection just after the tourniquet application and at 1 day and 2 days after the reperfusion. RESULTS: In the Group O (+), mechanical (von Frey hair) and cold (acetone exposure) allodynia were evident in the affected hindpaw as early as 1 day after reperfusion; this was extended for 2 weeks and it spread to the uninjured contralateral hindpaw. In the Group ON (+), the mechanical and cold allodynia were attenuated compared to those rats of Group O (+). CONCLUSIONS: NAC, a free radical scavenger, was able to reduce mechanical and cold allodynia in this model, and the generation of ROS is partly responsible for CRPS-I.
Key Words: allodynia, complex, regional, pain, syndrome, type, I
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