Blood Pressure Stabilizing Effect of Nicardipine at Endotracheal Intubation during Cesarean Section under General Anesthesia

Kim, Hong Soon; Lee, Kyung Cheon; Jung, Wol Seon; Park, Yeon Soo; Lee, Dongchul

Clinical Research

Obstetric Anesthesia

Anesthesia and Pain Medicine 2006;1(2):111-115.
Published online October 30, 2006.

Blood Pressure Stabilizing Effect of Nicardipine at Endotracheal Intubation during Cesarean Section under General Anesthesia

Hong Soon Kim, Kyung Cheon Lee, Wol Seon Jung, Yeon Soo Park, Dongchul Lee

Department of Anesthesiology and Pain Medicine, Gil Hospital, Gachon University, Incheon, Korea. suasdad@nate.com

Abstract

BACKGROUND
General anesthesia for cesarean section is usually maintained at a low dose after induction with using other agents. Many anesthesiologists have experience difficulty in maintaining stable blood pressure at intubation, as compared with nonobstetric anesthesia. We wanted to determine the efficacy of nicardipine for treating rising blood pressure that is related to intubation. METHODS: Twenty one parturient women, who were scheduled for elective cesarean section, were randomly allocated to two groups. Group 1 (n = 10) received no nicardipine and group 2 (n = 11) received nicardipine (7microg/kg) 60 seconds before intubation. The systolic blood pressures, diastolic blood pressures and heart rates were measured at preoperation, after induction of anesthesia, before intubation, immediately after intubation and at 1, 5, 10, 15 and 30 minutes after intubation. RESULTS: The systolic and diastolic blood pressures were lower in group 2 than group 1 at immediate after intubation. Yet the heart rate was higher in group 2 than in group 1 at the same time. CONCLUSIONS: Intravenous nicardipine given 60 seconds before intubation has some benefit from the viewpoint of blood pressure stability at intubation during cesarean section.

Key Words: cesarean section, endotracheal intubation, nicardipine